This game is just too good to not have its own thread. I still play it regularly while listening to music or podcasts or whatever, because it's always fun. Basically it's an archetypical roguelike. Every playthrough is different and there are no savestates. As is McMillen's style, the art style is also pretty interesting by combining relatively cute drawings with really grim and horrifying subject matter. However, since there are so many items in the damn thing, particularly with the Wrath of the Lamb DLC, you hardly can play it without having the Wiki open in the background.
Today I managed to beat Satan for like the 2nd time or so. I did so with Cain having a fully upgraded Meat Boy and a Ghost Baby tow, while having previously traded two Hearts for Spirit of the Night (because the ability to fly is just one of the best things you can have in this game. I basically always trade life containers for an item that gives flight). Managed to sustain myself by using the Safety Cap as my Trinket spawning Pills for me, and a Book of Revelations. Never found a Health upgrade other than Health Up pills, but thanks to Cain's Lucky Foot I can't find bad pills so it's a safe gamble. Went into Satan with more than the entire top right in Soul Hearts and 4 full red Hearts, and killed him with 1 or 2 red hearts left. That fucker is really hard to kill.