I watched this when it first popped up on Kotaku a while ago and I think Scott made it his TotD, but I never really got into it until a few weeks ago because of the constant references being made about it by some friends.
At first glance, it seems like nothing too special. It's a Japanese television show that started in 2003 with a format that pretty much everyone on the internet is probably sick of by now, i.e. "guy plays retro video games that are really hard yielding entertaining results."
GameCenter CX is definitely something more than that, however. Arino isn't your typical TV personality; he is soft-spoken, humble, and genuine. He's definitely a funny guy, but doesn't forcibly try and crack jokes in the way you might expect. The show has a TON of heart, and the film crew makes no attempt to conceal their audible laughter, excited cheering, and disappointment at Arino's quips, triumphs, and failures.
I highly recommend this show, here's a few select episodes to get you started. Takeshi's Challenge
and Mystery of Atlantis
are two of the most classic episodes. I also really liked Super Mario Bros 2 (The Lost Levels)
and the Pokemon Special, which has a very good interview with Satoshi Tajiri and a revisit of SMB2(Part 1
and Part 2